Overview of genetic data available


Our studies also collect genetic data, which isn't listed within CLOSER Discovery yet. A summary of genetic data in CLOSER studies, with links to accessing this data can be seen below.


Study name Respondent Number of respondents genotyped Method Data availability Sample used for DNA extraction Link to data access information
Avon Longitudinal Study of Parents and Children Study member 1,518 Illumina 317 Available Blood or Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Study member 3,233 Illumina 610 Available Blood or Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Study member 1,867 NGS (HiSeq ~6.5x) Available Blood or Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Study member 8,365 Illumina 550 (custom) Available Blood or Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Mother 8,340 Illumina 660 Available Blood or Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Mother and study member pairs 18,000 Illumina 660 + Illumina 550 (custom) Available Blood or Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Mother and father pairs 3,000 Illumina Core Exome Available Blood or Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Mother, father and study member triad 20,000 CNV data Available Blood or Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Study member 869 Illumina Human HT-12 V3 BeadChips (Expression data) Available Immortalised LCL http://www.bristol.ac.uk/alspac/researchers/access
Mother and study member pairs 1,000 Illumina Infinium 450k methylation array Available Blood http://www.bristol.ac.uk/alspac/researchers/access
1970 British Cohort Study Study member In field To be determined Coming when funding available Blood N/A
Hertfordshire Cohort Study Study member 967 Illumina Global Screening Array-24 Available Blood N/A
Millennium Cohort Study Mother, father and cohort member triad 21,192 Infinium global screening arrays-24 v1.0 Available Saliva https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Mother, father and cohort member triad 21,192 Imputed data Available Saliva https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
1958 National Child Development Study Study member 1,502 Affymetrix 500K Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 2,997 Affymetrix v6 Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 6,644 Dynal RELI SSO assay Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 2,922 Illumina 1.2M Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 1,475 Illumina 15K Custom chip Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 1,000 Illumina HiSeq 2500 Available Immortalised LCL https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 871 Illumina Human 660-Quad Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 6,894 Illumina ImmunoBeadShip – Illuminus, GenoSNP Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 5,840 Illumina Metabochip Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 1,436 Infinium 550K v1.1 Available Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 2,592 Infinium HumanHap 550K v3 Available Blood or Immortalised LCL https://ega-archive.org/datasets *
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member 542 MethylationEPIC BeadChip Available Immortalised LCL https://research.ncl.ac.uk/d2k/ourresearch/58forwards/methylation/ **
https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
Study member ~6000 ( when being combined) Imputed data Available Immortalised LCL https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples **
MRC National Survey of Health and Development Study member 2,464 Illumina Metabochip Available Blood https://skylark.ucl.ac.uk/NSHD/doku.php?id=mrepo:topics:biologicalsamplesanddna
Study member 2,870 Illumina DrugDev Custom chip Available Blood https://skylark.ucl.ac.uk/NSHD/doku.php?id=mrepo:topics:biologicalsamplesanddna
Study member 2,793 Illumina NeuroX2 chip Available Blood https://skylark.ucl.ac.uk/NSHD/doku.php?id=mrepo:topics:biologicalsamplesanddna
Southampton Women's Survey Study member 1,893 Illumina HumanOmniExpress-24 Available Cord blood N/A
Mother 967 Illumina Global Screening Array-24 Available Blood N/A
Understanding Society Study member 10,000 Illumina human core exome array Available Blood https://ega-archive.org/datasets *
https://www.understandingsociety.ac.uk/documentation/health-assessment/accessing-data **
Wirral Child Health and Development Study Study member 283 VNTR analyses*** Available Saliva https://www.liverpool.ac.uk/population-health/research/groups/first-steps/for-researchers
Study member 181 DNA Methylation Analysis*** Available Saliva https://www.liverpool.ac.uk/population-health/research/groups/first-steps/for-researchers

* when genetic data only is requested

** when genetic data is to be linked with other (non-genetic) phenotype/survey data from the study

***Wirral Child Health and Development Study completed targeted VNTR analyses for a small number of specific genes, as well as targeted epigenetic analyses examining methylation levels on key genes of theoretical interest to the study.